Axsome Therapeutics, Inc. (AXSM) - Stock Analysis

Last updated: Sep 5, 2026

Research Idea

Research content for general circulation. Not individualized advice. Methodology & Disclosures

Strong near-term catalyst stack: FDA approved AUVELITY for agitation associated with dementia due to Alzheimer's disease on 2026-04-30/05-01, Q1 2026 product revenue rose 57% YoY to $191.2M, NDA submitted for AXS-12, SUNOSI patent settlement extended protection, and the stock is up about 33% over 21 trading days.

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Idea window: 5/5/2026 – 5/12/2026Sector: Healthcare

AI Analyst Overview

Last Price
$220.75
Market Cap
$11.36B
1D Return
+4.56%
YTD Return
+20.87%

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Valuation Metrics

P/E
-58.9
P/B
136.5
P/S
14.6
EV/EBITDA
-64.2
Div Yield
—

Fundamental Analysis

4.0

Key Financial Insights: • Narrowing cash burn • Rising leverage • Negative profitability AXSM's improving losses and strong 94% gross margins are outweighed by continued cash burn, equity-financing dependence, rising leverage, and demanding valuation—favor caution.

HighMargins
HighRisk

Price Behavior

4.0

Key Price Behavior Insights: • Stalled rebound • Weak momentum • Key support Support Level: $198.00–$203.00 Resistance Level: $210.00, then $220.00–$221.00 AXSM is cautiously neutral-to-bearish over the last month, with a stalled rebound below $210 and downside risk if $198–203 support breaks.

AXSM
TechnicalAnalysis

Sentiment & News

6.0

Key News Insights: • AUVELITY Growth • Pipeline Expansion • Profitability Risk Axsome's strong AUVELITY-led growth and pipeline progress support momentum, but ongoing losses, revenue miss, and insider selling temper the outlook.

Axsome
BiotechGrowth
AI

AI Summary

5.0
Neutral

AXSM is evolving into a high-growth specialty pharma led by AUVELITY, but its ~83% revenue concentration, ongoing cash burn, and premium valuation mean investors should require sustained revenue beats and clear progress toward self-funded profitability before adding aggressively.

GrowthOpportunity
ConcentrationRisk
Profitability
AI summary updated 6 days ago

Description

Axsome Therapeutics is a U.S.-based biopharmaceutical company developing treatments for central nervous system disorders. Its late-stage pipeline includes a depression candidate (AXS-05) with additional trials in Alzheimer's-related agitation and prior smoking cessation data, a migraine treatment that completed Phase III testing (AXS-07), and Phase III programs for narcolepsy (AXS-12) and fibromyalgia (AXS-14). The company has a research collaboration with Duke University and was founded in 2012 in New York City.

Idea History

DateCloseTickerCompanySummaryStatusP/L
May 5May 12AXSMAxsome Therapeutics, Inc.
Strong near-term catalyst stack: FDA approved AUVELITY for agitation associated with dementia due to Alzheimer's disease on 2026-04-30/05-01, Q1 2026 product revenue rose 57% YoY to $191.2M, NDA submitted for AXS-12, SUNOSI patent settlement extended protection, and the stock is up about 33% over 21 trading days.
Closed+0.4%
Jan 1Jan 8AXSMAxsome Therapeutics, Inc.
Axsome Therapeutics is a hot idea with key upcoming FDA priority review of AXS-05 and NDA filing for AXS-12, strong Q3 revenue growth, and robust technical momentum. Despite operating losses and governance risks, its near-term regulatory catalysts provide potential for significant short-term price appreciation.
Closed-8.3%
Research content for educational purposes only. Not investment advice. All decisions are your responsibility.