Pulse Biosciences, Inc. (PLSE) - Stock Analysis

Last updated: Sep 19, 2026

Research Idea

Research content for general circulation. Not individualized advice. Methodology & Disclosures

High-impact AFib feasibility data and FDA IDE for NANOPULSE-AF, plus an upcoming Q4 call, have driven a ~66% 21-day surge and clear breakout; with minimal revenue and cash-burn risk this is a speculative but genuinely news-driven short-term hot momentum name.

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Idea window: 2/18/2026 – 2/25/2026Sector: Healthcare

AI Analyst Overview

Last Price
$52.66
Market Cap
$3.76B
1D Return
-0.68%
YTD Return
+283.54%

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Valuation Metrics

P/E
-45.0
P/B
36.6
P/S
3169.5
EV/EBITDA
-47.2
Div Yield
—

Fundamental Analysis

5.0

Key Financial Insights: • Improving Margins • Strong Liquidity • Ongoing Dilution PLSE's operating metrics and liquidity improved, but persistent losses, negative cash flow, dilution, and an extreme valuation warrant caution.

LiquidityStrength
HighValuation

Price Behavior

6.0

Key Price Behavior Insights: • Constructive uptrend • $55 resistance • $49 risk Support Level: $49.00–$50.00; stronger support $47.50–$48.80 Resistance Level: $55.20 PLSE remains constructively bullish over the last month, but a break above $55.20 favors continuation while a sustained drop below $49 signals correction risk.

PLSE
Volatility

Sentiment & News

6.0

Key News Insights: • Study Enrollment Complete • Analyst Buy Rating • Institutional Buying Pulse Biosciences gained investor and analyst momentum while advancing its thyroid-nodule clinical program through completed enrollment.

ClinicalProgress
InvestorInterest
AI

AI Summary

5.0
Neutral

PLSE has shifted from a funding-survival story to a high-valuation clinical-conversion bet: its strong cash position can fund key trials, but investors should demand compelling PRECISE-BTN and NANOPULSE-AF efficacy, safety, and adoption evidence before underwriting further upside, as delays or mixed data could trigger dilution and sharp downside.

ClinicalCatalyst
ValuationRisk
Medtech
AI summary updated 37 days ago

Description

Pulse Biosciences, Inc. is a bioelectric medicine company that develops the CellFX System, a console-based platform that delivers nanosecond electrical pulses (Nano-Pulse Stimulation) to non-thermally remove targeted cells while sparing surrounding non-cellular tissue. The company was incorporated in 2014, changed its name from Electroblate, Inc. to Pulse Biosciences in December 2015, and is headquartered in Hayward, California.

Idea History

DateCloseTickerCompanySummaryStatusP/L
Feb 18Feb 25PLSEPulse Biosciences, Inc.
High-impact AFib feasibility data and FDA IDE for NANOPULSE-AF, plus an upcoming Q4 call, have driven a ~66% 21-day surge and clear breakout; with minimal revenue and cash-burn risk this is a speculative but genuinely news-driven short-term hot momentum name.
Closed-24.6%
Feb 11Feb 18PLSEPulse Biosciences, Inc.
FDA IDEs for NANOPULSE‑AF and nPulse 360 EP plus strong first‑in‑human ablation data (150 patients, presented 2026‑02‑05) triggered a ~75% three‑day jump and price ~55% above its 21‑day SMA, making PLSE a high‑volatility clinical‑catalyst momentum trade into the 2026‑02‑19 earnings update.
Closed+0.8%
Research content for educational purposes only. Not investment advice. All decisions are your responsibility.